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Abstinence in recently detoxified AUD patients is subtended by increased inhibitory neural resources: A retrospective event-related potentials study

par Campanella, Salvatore ;Sistiaga, Sonia ;Dousset, Clémence ;Ingels, Anais ;Hanak, Catherine ;Hein, Matthieu ;Kajosch, Hendrik
Référence International journal of psychophysiology, 214
Publication Publié, 2025-06-25

Article révisé par les pairs

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Résumé :

A lack of inhibitory resources contributes to the onset and the maintenance of addictive behaviors, reflecting aninability to control impulses to consume. Enhancing inhibitory control has been therefore acknowledged tosupport abstinence in alcohol use disorder (AUD) patients. In the present retrospective study, we analyzed datafrom 32 AUD inpatients who underwent a three-week detoxification program (at the CHU Brugmann, Brussels,Belgium). During their hospital stay, they completed a test-retest event-related potentials (ERPs) Go-Nogo task,using neutral versus alcohol-related contexts. The first session (T0) took place approximately 4–7 days afteradmission, once withdrawal symptoms had subsided, and the second (T1) occurred just before discharge, around15 days later. Follow-up data on drinking behavior were collected three months after discharge to assess the rateof abstinence versus relapse. The primary objective was to assess whether three-month abstinent patients werethose who exhibited a significant increase in the amplitude of the Nogo P3 component at the end of thedetoxification program (T1 > T0), compared to those who relapsed. The main result of this study was that anincrease in the Nogo P3 component appeared to act as a protective factor against early relapse in detoxified AUDpatients. Such data could have important clinical implications, enabling clinicians to identify detoxified AUDpatients at high risk of relapse and guide them toward tailored, individualized cognitive rehabilitation programs.