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Copper-Catalyzed Trifluoromethylation of Vinylsiloxanes

par Grosso, Simone ;Marchese, Michela;Salamone, Logan;Riant, Olivier;Evano, Gwilherm
Référence ACS Catalysis, 15
Publication Publié, 2025-12-06

Article révisé par les pairs

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Résumé :

Trifluoromethylated alkenes are shown to be readily synthesized from the corresponding vinylsiloxanes using a simple copper-catalyzed trifluoromethylation with Umemoto’s reagent II. Upon simple activation with tetrabutylammonium triphenyldifluorosili-cate in the presence of Kubas’ salt and without an additional exogenous ligand, they were indeed found to be easily trifluoro-methylated with high levels of stereospecificity. In addition to a broad substrate scope and mild reaction conditions, this route to trifluoromethylated alkenes enables the synthesis of all E, Z and branched isomers.