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Diversity of immunization strongly impacts SARS-CoV-2 antibody function surrogates

par Levast, Benoît;Becker, Jérémie;Saade, Carla;VuDuc, Inès;Reynaud, Kendra;Broc, Camilo;Mignon, Charlotte;Mariano, Natacha;Donnat, Stéphanie;Yu, Shin Yi;Saliou, Adrien;Tran, Viet Dung;Vratskikh, Oxana;Couturier, Céline;Geoffroy, Stéphanie;Tranchot, Anely;Vedrine, Christophe;Perisse, Tom;Bruyere, Lily;Killian, Martin;Pozzetto, Bruno;Henaff, Laetitia;Saadatian-Elahi, Mitra;Vanhems, Philippe;Trabaud, Mary Anne;Massardier-Pilonchéry, Amélie;Guibert, Nicolas;Fassier, Jean-Baptiste;Escuret, Vanessa;d’Aubarede, Constance;Bal, Antonin;Alfaiate, Dulce;Louis, Karen;Beloeil, Laurent;Guyard, Cyril;Paul, Stéphane;Marchant, Arnaud ;Trouillet-Assant, Sophie
Référence NPJ vaccines, 10, 1, 175
Publication Publié, 2025-12-01

Article révisé par les pairs

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Résumé :

System serology offers a comprehensive approach to evaluate the humoral immune response by evaluating multiple parameters. In the present study, based on four groups of individuals with a different history of SARS-CoV-2 immunization, we analyzed the serum of 180 individuals based on six serological methods to better decipher their immunity. Through our analysis, against different SARS-CoV-2 antigens or variants, we report the importance of system serology to better decipher population immunity. Fc-dependent parameters are key factors underlying the variability of humoral immune response triggered by different schemes of SARS-CoV-2 immunization. With an evolving exposure to new variants, the acquisition of robust cross-reactive Fc-dependent effector functions are likely to be key to control viral replication when neutralizing antibodies are poorly cross-reactive. As booster vaccination remains a useful tool in periodically bolstering humoral immunity, particularly in vulnerable populations, studies should continue to evaluate the humoral immune response using system serology approach.