par Siminska-Stanny, Julia 
;Jafari, Hafez ;Wei, Qianqian ;Mirzaei, Mahta ;Shavandi, Armin
Référence (4-5 November 2025), GeSIM 30th anniversary event, Invited talk
Publication Publié, 2025-11-04
;Jafari, Hafez ;Wei, Qianqian ;Mirzaei, Mahta ;Shavandi, Armin Référence (4-5 November 2025), GeSIM 30th anniversary event, Invited talk
Publication Publié, 2025-11-04
Abstract de conférence
| Résumé : | The GeSiM BioScaffolder has been central to our recent investigations in biofabrication, providing high precision and reproducibility for a wide range of biomaterials. Using extrusion-based printing, alginate/poly(vinyl alcohol) hydrogels incorporating magnetic nanoparticles were fabricated, allowing for controlled deposition and enabling constructs with tunable stiffness and cytocompatibility relevant to neural applications. Marine- and phenol-derived inks were investigated for shape fidelity, and dual-crosslinked tyramine-modified hyaluronic acid/gelatin methacrylate hydrogels were established, which retained their architecture and demonstrated in vivo biocompatibility in salivary gland models. For wound healing, protein–polyphenol and marine saccharide hydrogels were formulated that exhibited injectability, self-healing capacity, antibacterial effects, and antioxidant activity. Bacterial exopolysaccharide-based inks were further evaluated, showing enhanced stability and sustainability compared with alginate.The melt electrowriting module of the BioScaffolder enabled fabrication of polycaprolactone microfibrous scaffolds with submicron resolution. Functionalization with yeast-derived bioactive peptides enhanced fibroblast proliferation, collagen deposition, and wound closure in vivo, providing a quantitative link between scaffold geometry, biochemical modification, and healing outcomes. Coaxial extrusion was employed to print perfusable PEG-tyramine vascular conduits that supported endothelial colonization and angiogenesis. Multimaterial 4D printing was further applied to construct patterned hydrogels with controlled distributions of magnetic nanoparticles, resulting in predictable, field-responsive behaviors such as bending, rolling, and jumping while maintaining cytocompatibility. Finally, visible-light responsive chitosan-based inks were formulated for extrusion, digital light processing, and volumetric printing, including a sacrificial system that could be selectively dissolved by light to create gravity-restricted geometries.This presentation will cover these advances, emphasizing how the modular capabilities of the GeSiM BioScaffolder including extrusion, coaxial printing, and melt electrowriting have enabled systematic studies linking biomaterial composition, printing parameters, and scaffold function in regenerative medicine. |
