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Retrospective Evaluation of the Prognostic Value of Histological Growth Pattern in Patients with Colorectal Peritoneal Metastases Undergoing Curative-Intent Cytoreductive Surgery.

par Kamdem, Leonel;Asmar, Antoine El;Demetter, Pieter ;Zana, Ismael Coulibaly;Khaled, Charif ;Sclafani, Francesco ;Donckier, Vincent;Vermeulen, Peter B.;Liberale, Gabriel
Référence Annals of surgical oncology, 31, 6, page (3778-3784)
Publication Publié, 2024-06-01

Article révisé par les pairs

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Résumé :

Two distinct histological growth patterns (HGPs) were described in patients with peritoneal metastasis of colorectal cancer origin (PMCRC) with limited Peritoneal Cancer Index (PCI) ≤ 6 who did not receive neoadjuvant chemotherapy (NAC) and were treated with cytoreductive surgery (CRS) ± hyperthermic intraperitoneal chemotherapy (HIPEC): pushing HGP (P-HGP) and infiltrating HGP (I-HGP). Patients with dominant P-HGP (> 50%) had significantly better disease-free survival (DFS) and overall survival (OS).