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Common mechanisms regulate stem cell self-organization and symmetry breaking across various glandular epithelia.

par Novello, Brigida ;Blanpain, Cédric
Référence Developmental cell, 60, 19, page (2537-2539)
Publication Publié, 2025-10

Article révisé par les pairs

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Résumé :

In this issue of Developmental Cell, Journot et al. identify a conserved mechanism promoting the development and lineage segregation of multipotent stem cells across different glandular epithelia. p63, YAP, and Notch control symmetry breaking, cell positioning, and cell-fate decision during development and regeneration, illustrating how spatial cues orchestrate tissue self-organization.