Mesalazine (5-aminosalicylic acid) induced chronic hepatitis.

Deltenre, Pierre; Berson, A; Marcellin, P; Degott, C; Biour, M; Pessayre, D

doi:doi/10.1136/gut.44.6.886

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Mesalazine (5-aminosalicylic acid) induced chronic hepatitis.

par Deltenre, Pierre

;Berson, A ;Marcellin, P ;Degott, C ;Biour, M ;Pessayre, D
Référence Gut, 44, 6, page (886-888)
Publication Publié, 1999-06

Article révisé par les pairs

Résumé :

Treatment of ulcerative colitis or Crohn's disease with sulphasalazine causes several adverse effects, including hepatitis. Sulphasalazine is cleaved by colonic bacteria into 5-aminosalicylic acid and sulphapyridine. Received wisdom was that 5-aminosalicylic acid was topically active, whereas sulphapyridine was absorbed and caused immunoallergic side effects. Mesalazine, a slow release formulation of 5-aminosalicylic acid, was expected to be a safe alternative. However, several cases of acute hepatitis have been reported.

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