Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids.

Louvet, Alexandre; Diaz, Emmanuel; Dharancy, Sébastien; Coevoet, Hugues; Texier, Frédéric; Thévenot, Thierry; Deltenre, Pierre; Canva, Valérie; Plane, Christophe; Mathurin, Philippe

doi:doi/10.1016/j.jhep.2007.10.010

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Early switch to pentoxifylline in patients with severe alcoholic hepatitis is inefficient in non-responders to corticosteroids.

par Louvet, Alexandre ;Diaz, Emmanuel ;Dharancy, Sébastien ;Coevoet, Hugues ;Texier, Frédéric ;Thévenot, Thierry ;Deltenre, Pierre

;Canva, Valérie ;Plane, Christophe ;Mathurin, Philippe
Référence Journal of hepatology, 48, 3, page (465-470)
Publication Publié, 2008-03

Article révisé par les pairs

Résumé :

In severe alcoholic hepatitis (AH), 40% of patients will obtain no benefit from corticosteroids. Improvement in management of non-responders is warranted and only pentoxifylline can be considered an alternative. A two-step strategy was evaluated consisting of early withdrawal of corticosteroids and a switch to pentoxifylline for 28 additional days in non-responders identified using early change in bilirubin level.

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