Article révisé par les pairs
Titre:
  • Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis.
Auteur:Strnad, Pavel; Buch, Stephan; Hamesch, Karim; Fischer, Janett; Rosendahl, Jonas; Schmelz, Renate; Brueckner, Stefan; Brosch, Mario; Heimes, Carolin CV; Woditsch, Vivien; Scholten, David; Nischalke, Hans Dieter; Janciauskiene, Sabina; Mandorfer, Mattias; Trauner, Michael; Way, Michael J; McQuillin, Andrew; Reichert, Matthias C; Krawczyk, Marcin; Casper, Markus; Lammert, Frank; Braun, Felix; von Schönfels, Witigo; Hinz, Sebastian; Burmeister, Greta; Hellerbrand, Claus; Teufel, Andreas; Feldman, Alexandra; Schattenberg, Joern M; Bantel, Heike; Pathil, Anita; Demir, Muenevver; Kluwe, Johannes; Boettler, Tobias; Ridinger, Monika; Wodarz, Norbert; Soyka, Michael; Rietschel, Marcella; Kiefer, Falk; Weber, Thomas S.; Marhenke, Silke; Vogel, Arndt; Hinrichsen, Holger; Canbay, Ali; Schlattjan, Martin; Sosnowsky, Katharina; Sarrazin, Christoph; von Felden, Johann; Geier, Andreas; Deltenre, Pierre; Sipos, Bence; Schafmayer, Clemens; Nothnagel, Michael; Aigner, Elmar; Datz, Christian; Stickel, Felix; Morgan, Marsha Yvonne; Hampe, Jochen; Berg, Thomas; Trautwein, Christian
Informations sur la publication:Gut, 68, 6, page (1099-1107)
Statut de publication:Publié, 2019-06-01
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:NASH
SERPINA1
alcoholic liver disease
alpha1-antitrypsin deficiency
fibrosis
MeSH keywords:Age Distribution
Austria
Biopsy, Needle
Case-Control Studies
Confidence Intervals
Female
Genetic Carrier Screening
Genetic Predisposition to Disease -- epidemiology
Genetic Variation
Germany
Heterozygote
Humans
Immunohistochemistry
Incidence
Liver Cirrhosis, Alcoholic -- epidemiology -- genetics -- pathology
Male
Non-alcoholic Fatty Liver Disease -- epidemiology -- genetics -- pathology
Odds Ratio
Polymorphism, Single Nucleotide
Prognosis
Risk Assessment
Sex Distribution
alpha 1-Antitrypsin -- genetics
Langue:Anglais
Identificateurs:urn:issn:0017-5749
info:doi/10.1136/gutjnl-2018-316228
info:pii/gutjnl-2018-316228
info:pmid/30068662

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