par Leproult, Rachel 
;Copinschi, Georges
Référence Sleep Medicine: A Comprehensive Guide to Its Development, Clinical Milestones, and Advances in Treatment, Springer Science+Business Media, page (443-450)
Publication Publié, 2015-01
;Copinschi, Georges Référence Sleep Medicine: A Comprehensive Guide to Its Development, Clinical Milestones, and Advances in Treatment, Springer Science+Business Media, page (443-450)
Publication Publié, 2015-01
Partie d'ouvrage collectif
| Résumé : | Epidemiological and laboratory studies, as well as clinical investigations in patients with sleep disorders, have provided strong evidence of a considerable impact of sleep restriction on endocrine–metabolic function. Both partial sleep deprivation (with a fairly good preservation of slow-wave sleep (SWS)) and SWS suppression or sleep fragmentation (with preservation of total sleep duration) result in a decreased glucose tolerance and/or decreased insulin sensitivity indicating a higher risk for diabetes. Sleep curtailment is also associated with reduced leptin (an anorexigenic hormone) and increased ghrelin (an orexigenic hormone) levels, together with an increase in hunger. In overweight subjects, moderate caloric restriction under sleep restriction condition results in increased hunger and loss of muscle mass rather than loss of fat mass. It is concluded that sleep restriction, a hallmark of modern society, is likely to play a role in the current development of obesity and type II diabetes epidemics. Future studies, incorporating objective measures of sleep duration and quality, should explore the potential benefits of sleep extension in short sleepers as a simple tool to reverse the adverse effects of sleep loss on diabetes and obesity risks. |
