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Dose-Dependent Regional Synchronicity Changes Using Weighted Phase Lag Index: Towards Optimizing Vagus Nerve Stimulation Titration Process

par Carcamo Cerda, Paloma;Aqueveque, Pablo;Nonclercq, Antoine ;El Tahry, Riëm ;Germany, Enrique
Référence (14-17 July, 2025: Copenhagen, Denmark), Proceedings of the 47th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Publication Publié, 2025-07

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Résumé :

Vagus Nerve Stimulation (VNS) is an effective therapy for drug-resistant epilepsy (DRE), but its efficacy varies. This study uses the weighted Phase Lag Index (wPLI) across multiple frequency bands to examine at an individual level dosedependent regional brain synchronization effect. EEG data from four DRE patients (two responders and two non-responders) were analyzed under controlled VNS intensities. Results show that non-responders exhibit an increased synchrony at higher intensity levels, particularly in the beta band and the broadband. Findings highlight individualized neural responses to VNS, underscoring the possibility for personalized stimulation strategies to optimize therapy.