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Knockdown of GAD67 protein levels normalizes neuronal activity in a rat model of Parkinson's disease.

par Horvath, Lazlo;Van Marion, Ingrid ;Taï, Khalid;Nielsen, Troels Tolstrup;Lundberg, Cecilia
Référence The journal of gene medicine, 13, 3, page (188-197)
Publication Publié, 2011-03

Article révisé par les pairs

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Résumé :

Dopamine depletion of the striatum is one of the hallmarks of Parkinson's disease. The loss of dopamine upregulates GAD67 expression in the striatal projection neurons and causes other changes in the activity of the basal ganglia circuit.