par Gemander, Nicolas
;Neumann, Julika;Veiga, Rafael;Etienne, Isabelle
;Prezzemolo, Teresa;Kemlin, Delphine
;Pannus, Pieter;Depickère, Stéphanie;Olislagers, Véronique
;Vu Duc, Inès;Waegemans, Alexandra
;Gerbaux, Margaux
;Bücken, Leoni;Dahma, Hafid
;Martin, Charlotte;Dauby, Nicolas
;Goossens, Maria M.E.;Desombere, Isabelle;Roca, Carlos P;Willemsen, Mathijs;Goriely, Stanislas
;Le Moine, Alain;Marchant, Arnaud
;Liston, Adrian;Humblet-Baron, Stéphanie
Référence NPJ vaccines, 10, 1, page (140)
Publication Publié, 2025-07










Référence NPJ vaccines, 10, 1, page (140)
Publication Publié, 2025-07
Article révisé par les pairs
Résumé : | Solid-organ transplant (SOT) recipients are at enhanced risk of infection and to poorly respond to vaccination due to comorbidities and immunosuppression. We performed a systems vaccinology study in 59 kidney and 31 lung transplant recipients who received 3 doses of COVID-19 mRNA BNT162b2 vaccine. We were able to characterize a baseline configuration associated with an effective humoral response to 3 doses, characterized by an innate and activated B cell profile, whereas a T cell signature was associated with a poorer response. We observed a distinct configuration associated with a detectable humoral response to 2 doses, partly mediated by double negative B cell subsets. These results suggest that, despite their immunosuppression, some SOT recipients can induce an effective humoral response to 3 doses of vaccine supported by a baseline configuration close to the healthy phenotype. Baseline immune phenotyping may help identify SOT recipients at the greatest risk of a poor vaccine response. |