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Systems vaccinology identifies immunological correlates of SARS-CoV-2 vaccine response in solid organ transplant recipients.

par Gemander, Nicolas ;Neumann, Julika;Veiga, Rafael;Etienne, Isabelle ;Prezzemolo, Teresa;Kemlin, Delphine ;Pannus, Pieter;Depickère, Stéphanie;Olislagers, Véronique ;Vu Duc, Inès;Waegemans, Alexandra ;Gerbaux, Margaux ;Bücken, Leoni;Dahma, Hafid ;Martin, Charlotte;Dauby, Nicolas ;Goossens, Maria M.E.;Desombere, Isabelle;Roca, Carlos P;Willemsen, Mathijs;Goriely, Stanislas ;Le Moine, Alain;Marchant, Arnaud ;Liston, Adrian;Humblet-Baron, Stéphanie
Référence NPJ vaccines, 10, 1, page (140)
Publication Publié, 2025-07

Article révisé par les pairs

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Résumé :

Solid-organ transplant (SOT) recipients are at enhanced risk of infection and to poorly respond to vaccination due to comorbidities and immunosuppression. We performed a systems vaccinology study in 59 kidney and 31 lung transplant recipients who received 3 doses of COVID-19 mRNA BNT162b2 vaccine. We were able to characterize a baseline configuration associated with an effective humoral response to 3 doses, characterized by an innate and activated B cell profile, whereas a T cell signature was associated with a poorer response. We observed a distinct configuration associated with a detectable humoral response to 2 doses, partly mediated by double negative B cell subsets. These results suggest that, despite their immunosuppression, some SOT recipients can induce an effective humoral response to 3 doses of vaccine supported by a baseline configuration close to the healthy phenotype. Baseline immune phenotyping may help identify SOT recipients at the greatest risk of a poor vaccine response.