par Naeije, Gilles 
;Georgiev, Christian ;Cabaraux, Pierre ;Bourguignon, Mathieu
Référence Clinical neurophysiology, page (2110744)
Publication Publié, 2025-05-01
;Georgiev, Christian ;Cabaraux, Pierre ;Bourguignon, Mathieu Référence Clinical neurophysiology, page (2110744)
Publication Publié, 2025-05-01
Article révisé par les pairs
| Résumé : | Objective: To determine the impact of cerebellar anatomy on ctDCS efficacy in individuals with Friedreich ataxia (FA). Methods: We included 24 FA patients (mean age 31 ± 14 years) and 24 age- and sex-matched healthy controls. Patients underwent a 5-day ctDCS intervention, with cerebellar motor and non-motor symptoms assessed using the Scale for the Assessment and Rating of Ataxia (SARA) and the Cerebellar Cognitive Affective Syndrome Scale (CCAS-S), before and after stimulation. MRI was used to measure cerebellar gray matter volume, superior cerebellar peduncle (SCP) diameter, and skin-to-cerebellum distance. Stepwise linear regression analyses examined predictors of motor and cognitive improvements following ctDCS. Results: FA patients exhibited significantly reduced cerebellar gray matter volume compared to controls (p = 0.024) after intracranial volume correction, skin-to-cerebellum distance did not differ between groups (p = 0.11). Stepwise linear regression analysis disclosed that the anterior cerebellar gray matter volume was a significant predictor of SARA improvement (β = −0.18, p < 0.001) and the posterior cerebellar gray matter volume of CCAS-S improvement (β = −0.13, p 0.023). Neither SCP diameter nor skin-to-cerebellum distance significantly impacted ctDCS efficacy. Conclusion: Cerebellar gray matter volume is associated to ctDCS-induced symptoms improvements in FA. Significance: These findings suggest that cerebellar gray matter volume influences ctDCS responsiveness. |
