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Nanozymes as catalysts for accelerated healing of diabetic wounds

par Li, Man;Jafari, Hafez ;Okoro, Oseweuba ;Nie, Lei ;Shavandi, Armin
Référence Cell Biomaterials, page (100049)
Publication Publié, 2025-04-01

Article révisé par les pairs

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Résumé :

Nanozymes have unique physicochemical properties such as enzyme-like activity, high surface-to-volume ratio, and the ability to mimic natural enzymes. Their catalytic antibacterial properties stem from their ability to generate reactive oxygen species (ROS), disrupt bacterial membranes, and modulate the wound environment to inhibit bacterial proliferation, offering extensive and promising applications for the medical care of diabetic wounds. In this review, the problems associated with diabetic wounds and the classification of nanozymes were introduced. Then the mechanisms of nanozyme action in diabetic wound healing are discussed in detail. Finally, the current challenges limiting the use of nanozymes to treat diabetic wounds were highlighted and critically analyzed.