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VNS-induced dose-dependent pupillary response in refractory epilepsy.

par Torres Sánchez, Andrés;Dawant, Marie ;Danthine, Venethia;Cakiroglu, Inci;Santalucia, Roberto ;Germany Morrison, Enrique ;Nonclercq, Antoine ;El Tahry, Riëm
Référence Clinical neurophysiology, 171, page (67-75)
Publication Publié, 2025-05-01

Article révisé par les pairs

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Résumé :

The Locus Coeruleus (LC) plays a vital role by releasing norepinephrine, which contributes to the antiepileptic effects of Vagus Nerve Stimulation (VNS). LC activity also influences pupil dilation. Investigating VNS dose-dependent Pupillary Dilation Response (PDR) may provide novel neurophysiological insights into therapeutic response and allow for an objective and personalized optimization of stimulation parameters.