par Goudsmit, Anouk 
;Brandão, Mariana ;Oullaï, Ali;Engelman, Dan ;Ghorra, Nathalie;Daif, Tarik ;Buelens, Tom;Meert, Anne-Pascale
Référence Respiratory medicine and research, 82, page (100966)
Publication Publié, 2022-11-01
;Brandão, Mariana ;Oullaï, Ali;Engelman, Dan ;Ghorra, Nathalie;Daif, Tarik ;Buelens, Tom;Meert, Anne-Pascale Référence Respiratory medicine and research, 82, page (100966)
Publication Publié, 2022-11-01
Article révisé par les pairs
| Résumé : | Optic neuritis with CRMP-5 IgG is a paraneoplastic inflammation of the optic nerve associated with lung cancer, mostly small-cell lung cancer. We present the case of a patient with lung adenocarcinoma who developed progressive bilateral visual loss a few months after immune-chemotherapy with pembrolizumab and after Covid-19 vaccination. Positive CRMP-5 IgG were detected in blood sample and complete work-up −including brain MRI - did not show any progression. High dose systemic corticoids were administered with transient improving, followed by intravenous immunoglobulins, methotrexate and rituximab but despite negativization of CRMP-5 IgG, the patient had a progressive visual loss |
