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Independent and Interacting Value Systems for Reward and Information in the Human Brain

par Cogliati Dezza, Irene ;Alexander, William;Cleeremans, Axel
Référence eLife, 11, e66358
Publication Publié, 2022-04-01

Article révisé par les pairs

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Résumé :

Theories of Prefrontal Cortex (PFC) as optimizing reward value have been widely deployed to explain its activity in a diverse range of contexts, with substantial empirical support in neuroeconomics and decision neuroscience. Similar neural circuits, however, have also been associated with information processing. By using computational modeling, model-based fMRI analysis, and a novel experimental paradigm, we aim at establishing whether a dedicated and independent value system for information exists in the human PFC. We identify two regions in the human PFC which independently encode reward and information. Our results provide empirical evidence for PFC as an optimizer of independent information and reward signals during decision-making under realistic scenarios, with potential implications for the interpretation of PFC activity in both healthy and clinical populations.