par Glinoer, Daniel 
;Nayer, Philippe De
Référence Thyroid Diseases: Clinical Fundamentals and Therapy, CRC Press, page (517-527)
Publication Publié, 2024-01
;Nayer, Philippe DeRéférence Thyroid Diseases: Clinical Fundamentals and Therapy, CRC Press, page (517-527)
Publication Publié, 2024-01
Partie d'ouvrage collectif
| Résumé : | Thyroid disorders are observed four- to fivefold more frequently in women, compared to men, in particular during the child-bearing period. It is therefore not unusual to encounter biochemical abnormalities of thyroid functioning during a “routine” laboratory check-up, carried out in pregnant women. One of the aims of this chapter is to underscore the rationale allowing for a correct interpretation of these alterations. Furthermore, pregnancy is associated with profound alterations in thyroidal economy due to the combination of three factors: the marked increase in the binding capacity of serum due to the rise in thyroxine-binding globulin levels (TBG); the stimulatory effect of placental factors, namely human chorionic gonadotropin (hCG) on the maternal thyroid; and the reduced availability of iodine which results primarily from an increased renal clearance of iodide. Finally, even though the general rules for the management of patients with thyroid disease are not different during pregnancy, some specific aspects dealing with the treatment and follow-up of patients ought to be underlined. |
