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DESIGN AND SYNTHESIS OF TRANSMEMBRANE TRANSPORTERS FOR PHOSPHATE

par Norvaisa, Karolis ;Cataldo, Alessio ;Halgreen, Lau ;Bodman, Samantha E.;Bartik, Kristin ;Butler, Stephen;Valkenier, Hennie
Référence Balticum Organicum Syntheticum 2024
Publication Publié, 2024-07-07

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Résumé :

Until recently, no synthetic transporters for inorganic phosphate were reported. However, in this report, we show a strapped calix[4]pyrrole with 8 H-bond donors that allows the extraction of strongly hydrated H2PO4− into the lipid bilayer while shielding its charges from the lipophilic bilayer interior and transferring this anion through the membrane.[1] Phosphate transport was monitored by emission spectroscopy using an encapsulated phosphate sensitive europium(III) probe.[2] Furthermore, 31P-NMR spectroscopy was used to confirm and identify the transported phosphate species.