• Citer

G1/S cyclins interact with regulatory subunit of PKA via A-kinase anchoring protein, AKAP95

par Arsenijevic, Tatjana ;Degraef, Chantal ;Dumont, Jacques Emile ;Roger, Pierre P. ;Pirson, Isabelle
Référence Cell Cycle, 5, 11, page (1217-1222)
Publication Publié, 2006

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

The mechanisms by which cyclins promote mammalian cell cycle progression have been a topic of intense investigation over the last decade. We previously described an interaction between D-type cyclins and A-kinase anchoring protein, AKAP95. Here, we demonstrate that AKAP95 can also bind cyclin E1. Association between AKAP95 and cyclins is displaced by CDKs. We show that these G(1)/S cyclins can interact with RII subunit of PKAalpha through AKAP95. The presence of alternate complexes cyclin-CDK and cyclin D/E-AKAP95-PKA.RIIalpha suggest different roles of G(1)/S cyclins and a wider biological importance of these interactions in cells.