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Multicentre interlaboratory analysis of routine susceptibility testing with a challenge panel of resistant strains

par Deckers, Corentin;Soleimani, Reza;Denis, Olivier ;Bogaerts, Pierre;Berhin, Catherine;Rodriguez-Villalobos, Hector;Descy, Julie;Hallin, Marie ;Nonhoff, Claire ;Desmet, Stefanie;Magerman, Koen;Van den Abeele, Anne-Marie;Lissoir, Bénédicte;Matheeussen, Veerle;Vernelen, Kris;Huang, Te-Din
Référence Journal of Global Antimicrobial Resistance, 28, page (125-129)
Publication Publié, 2022-03

Article révisé par les pairs

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Résumé :

Objectives: In order to elaborate a new national challenge panel of resistant Gram-negative bacilli and Gram-positive cocci strains for the validation of routine antimicrobial susceptibility testing (AST) methods, an interlaboratory evaluation was organised. Methods: The results of 12 well-characterised multidrug-resistant strains tested by nine laboratories using local disk diffusion (DD) and automated AST (AUST) methods were compared with the reference broth microdilution method. Results: Overall categorical agreement ranged from 70% to 100% both for DD and AUST and was >90% for all but one strain for all antibiotics. Conclusion: Our multicentre AST study showed good reproducibility and the panel can be used as national resistant reference strains for routine AST validation.