par Siminska-Stanny, Julia 
;Podstawczyk, Daria;Delporte, Christine ;Nie, Lei ;Shavandi, Armin
Référence Advanced Healthcare Materials
Publication Publié, 2024-09-10
;Podstawczyk, Daria;Delporte, Christine ;Nie, Lei ;Shavandi, Armin Référence Advanced Healthcare Materials
Publication Publié, 2024-09-10
Article révisé par les pairs
| Résumé : | Tissue vascularization is a major challenge and a bottleneck in tissue engineering. In this review, we explore state of the art on the intricate role of hyaluronic acid (HA) in angiogenesis. HA plays a twofold role in angiogenesis. Firstly, when released as a free polymer in the extracellular matrix (ECM), HA acts as a signaling molecule triggering multiple cascades that foster smooth muscle cells differentiation, migration, and proliferation thereby contributing to vessel wall thickening. Simultaneously, HA bound to the plasma membrane in the pericellular space functions as a polymer block, participating in vessel formation. Starting with the HA origins in native vascular tissues, we review the approaches aimed at achieving vascularization in vivo. The significance of HA molecular weight (MW) in angiogenesis is reviewed and we conscientiously address the challenges associated with utilizing HA in vascular tissue engineering (VTE). The review finally focuses on a thorough examination and comparison of the diverse strategies adopted to harness the benefits of HA in the vascularization of bioengineered materials. By providing a nuanced perspective on the multifaceted role of HA in angiogenesis, this review contributes to the ongoing discourse in tissue engineering and advances our collective understanding of optimizing vascularization processes assisted by functional biomaterials. |
