par Wang, Ling;Ding, Xiaoyue;Li, Jingyu;Li, Man;Ding, Peng;Guo, Wei;Wu, Qiaoyun;Sun, Yanfang;Jiang, Guohua;Okoro, Oseweuba Valentine;Mirzaei, Mahta 
;Shavandi, Armin ;Fan, Lihong;Nie, Lei
Référence Biomedical Materials (Bristol), 19, 4, page (045042)
Publication Publié, 2024-09-01
;Shavandi, Armin ;Fan, Lihong;Nie, LeiRéférence Biomedical Materials (Bristol), 19, 4, page (045042)
Publication Publié, 2024-09-01
Article révisé par les pairs
| Résumé : | Abstract Bacterial infection can lead to various complications, such as inflammations on surrounding tissues, which can prolong wound healing and thus represent a significant clinical and public healthcare problem. Herein, a report on the fabrication of a novel genipin/quaternized chitosan (CS) hydrogel for wound dressing is presented. The hydrogel was prepared by mixing quaternized CS and genipin under 35 °C bath. The hydrogels showed porous structure (250–500 μm) and mechanical properties (3000–6000 Pa). In addition, the hydrogels displayed self-healing ability and adhesion performance on different substrates. Genipin crosslinked quaternized CS hydrogels showed antibacterial activities against E. coli and S. aureus . The CCK-8 and fluorescent images confirmed the cytocompatibility of hydrogels by seeding with NIH-3T3 cells. The present study showed that the prepared hydrogel has the potential to be used as wound dressing. |
