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Rigorous Donor Selection for Fecal Microbiota Transplantation in Active Ulcerative Colitis: Key Lessons From a Randomized Controlled Trial Halted for Futility.

par Caenepeel, Clara;Deleu, Sara;Vazquez Castellanos, Jorge Francisco;Arnauts, Kaline;Braekeleire, Sara;MacHiels, Kathleen;Baert, Filip;Mana, Fazia;Pouillon, Lieven;Hindryckx, Pieter P.M.;Lobaton, Triana;Thomas, Elizabeth Louise E.;Franchimont, Denis ;Verstockt, Bram;Ferrante, Marc;Sabino, João;Vieira-Silva, Sara;Falony, Gwen;Raes, Jeroen JR;Vermeire, Séverine
Référence Clinical gastroenterology and hepatology
Publication Publié, 2024-05-01

Article révisé par les pairs

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Résumé :

Rigorous donor preselection on microbiota level, strict anaerobic processing, and repeated fecal microbiota transplantation (FMT) administration were hypothesized to improve FMT induction of remission in ulcerative colitis (UC).