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Endoscopic submucosal dissection for rectal neuroendocrine tumours: A multicentric retrospective study

par Rimondi, Alessandro;Despott, Edward;Chacchi, Rocio;Lazaridis, Nikolaos;Costa, Deborah;Bucalau, Ana-Maria ;Mandair, Dalvinder;Pioche, Mathieu;Rivory, Jérôme;Santos-Antunes, João;Marques, Margarida;Ramos-Zabala, Felipe;Barbaro, Federico;Pimentel-Nunes, Pedro;Dinis-Ribeiro, Mário Jorge M.;Albeniz, Eduardo;Tantau, Marcel;Spada, Cristiano;Lemmers, Arnaud ;Caplin, Martyn Evan;Toumpanakis, Christos;Murino, Alberto
Référence Digestive and Liver Disease
Publication Publié, 2024-10-01

Article révisé par les pairs

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Résumé :

Introduction: Endoscopic Submucosal Dissection (ESD) has been reported as a feasible and effective treatment for Rectal Neuroendocrine Tumours (R-NETs). However, most of the experience on the topic comes from retrospective tertiary centre from Eastern Asia. Data on ESD for R-NETs in Western centres are lacking. Materials and Methods: This is a retrospective study, including patients who underwent endoscopic resection of R-NETS by ESD between 2015 and 2020 in Western Centres. Important clinical variables such as demographic, size of R-NETs, histological type, presence of lymphovascular invasion or distant metastasis, completeness of the endoscopic resection, recurrence, and procedure related complications were recorded. Results: 40 ESD procedure on R-NETs from 39 patients from 8 centres were included. Mean R-NETs size was 10.3 mm (SD 4.01). Endoscopic en-bloc resection was achieved in 39/40 ESD (97.5 %), R0 margin resection was obtained in 87.5 % (35/40) of the procedures, one patient was referred to surgery for lymphovascular invasion, two procedures (5 %) reported significant episodes of bleeding, whereas a perforation occurred in one case (1/40, 2.5 %) managed endoscopically. Recurrence occurred in 1 patient (2.5 %). Conclusion: ESD is an effective and safe treatment for R-NETs in western centres.