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Absence of meningeal mast cells in the Mitf mutant mouse

par Sabaté San José, Alba ;Petersen, Petur Henry
Référence Frontiers in Cellular Neuroscience, 18, 1337621
Publication Publié, 2024

Article révisé par les pairs

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Résumé :

Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response in vivo. In this study, we illustrate that a mutation in microphthalmia-associated transcription factor (Mitf) affects meningeal MC number in a dosage-dependent manner. C57BL/6J Mitf null mice lack meningeal MCs completely, whereas heterozygous mice have on average 25% fewer MCs. Mitf heterozygous mice might be a valuable tool to study the role of MCs in the meninges.