par Hadefi, Alia 
;Devière, Jacques
Référence Innovations in Gastrointestinal Endoscopy, Springer Singapore, page (153-159)
Publication Publié, 2021-01
;Devière, Jacques Référence Innovations in Gastrointestinal Endoscopy, Springer Singapore, page (153-159)
Publication Publié, 2021-01
Partie d'ouvrage collectif
| Résumé : | Type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) are pandemic metabolic disorders. In fact, NAFLD is now the leading cause of liver disease in developed countries. Despite several therapies, including medications and weight loss, most patients do not achieve treatment goals. Bariatric surgery is currently considered to be the only approach that can lead to partial or complete remission of T2DM and has highlighted the metabolic role of the duodenum in glucose metabolism. Based on this finding, a novel, minimally invasive endoscopic approach, duodenal mucosal resurfacing, has been developed to ablate the duodenal mucosa in order to induce its regeneration. This review focuses on the role of the duodenum in the regulation of glucose and lipid homeostasis and the current clinical data available regarding duodenal mucosal resurfacing in T2DM and NAFLD. This new therapeutic procedure promises to become part of the therapeutic armamentarium for diabetic and obese patients and, more widely, for metabolic disorders. |
