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Mild COVID-19 among pregnant women managed with home self-isolation in Lebanon: A prospective cohort study

par Ramadan, Mohamad M.K.;Saleh, Nadine;Dimachkieh, Khouloud;Itani, Saad Eddine;Itani, Jamal;Badr, Dominique
Référence Perinatal Journal, 31, 2, page (141-147)
Publication Publié, 2023-08

Article révisé par les pairs

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Résumé :

Objective: Although mild coronavirus disease 2019 comprises the vast majority of cases during and after pregnancy, it has not been adequa-tely explored, and the medical course and pregnancy outcomes remain enigmatic. This study aimed to describe the course of mild corona-virus disease 2019 infection during pregnancy among non-hospitalized women and assess the short-and mid-term maternal and neonatal outcomes. Methods: This was a prospective cohort study of successive cases of confirmed COVID-19 infection during pregnancy with no or mild sy-mptoms. Patients with severe or critical disease were excluded. The included patients were followed regularly throughout pregnancy and at least three months after delivery. Outcomes included composite adverse maternal outcomes (early pregnancy loss, preterm birth, gestational diabetes mellitus, or gestational hypertension/preeclampsia) and composite adverse neonatal outcomes (neonatal intensive care unit admissi-on, small for gestational age, congenital anomalies, or neonatal death). The incidence of long COVID-19 was also calculated. Results: Seventy-two cases were available for analysis (n=20, n=31, and n=21 were infected during the first, second, and third trimesters, respectively). Of them, 29 (40.2%) were asymptomatic at diagnosis. The most common symptoms were fatigue, fever, and myalgia. Adverse pregnancy outcomes were rare. No difference was observed between symptomatic and asymptomatic patients. Moreover, infection timing did not impact outcomes. The overall frequency of long coronavirus disease 2019 was approximately 47.2%. Conclusion: Mild Covid-19 infection during pregnancy is associated with a favorable prognosis. Similar to non-pregnant infected individu-als, it may progress to more severe forms and Long-Covid-19 may persist.