par Hadefi, Alia 
;Devière, Jacques
Référence Gastrointestinal and Pancreatico-Biliary Diseases: Advanced Diagnostic and Therapeutic Endoscopy: With 558 Figures and 150 Tables, Springer International Publishing, page (787-794)
Publication Publié, 2021-01
;Devière, Jacques Référence Gastrointestinal and Pancreatico-Biliary Diseases: Advanced Diagnostic and Therapeutic Endoscopy: With 558 Figures and 150 Tables, Springer International Publishing, page (787-794)
Publication Publié, 2021-01
Partie d'ouvrage collectif
| Résumé : | Type 2 diabetes mellitus (T2DM) is a metabolic disorder of pandemic scale, and its complications have largely contributed to the burden of mortality and disability worldwide. Despite several therapies including medications or weight loss, most of patients do not achieve treatment goals. Bariatric surgery is currently considered as the only approach which might even lead to partial or complete remission of T2DM and has highlighted the metabolic role of the duodenum in glucose metabolism. Based on these considerations, a novel minimally invasive endoscopic approach, duodenal mucosal resurfacing, was designed whose purpose is to ablate the duodenal mucosa in order to induce its regeneration. This review highlights the role of the duodenum in the regulation of glucose and lipid homeostasis and the current clinical data available regarding duodenal mucosal resurfacing in T2DM. This new promising therapeutic procedure might become part of the therapeutic armamentarium for T2DM and more widely for metabolic disorders. |
