Titre:
  • A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases
Auteur:Al-Thani, Maha; Goodwin-Trotman, Mary; Bell, Steven; Patel, Krushangi; Fleming, Lauren L.K.; Vilain, Catheline; Abramowicz, Marc; Allan, Stuart Mc Rae S.M.; Wang, Tao; Cader, Zameel M.Z.; Horsburgh, Karen; van Agtmael, Tom; Sinha, Sanjay; Markus, Hugh Stephen; Granata, Alessandra
Informations sur la publication:Stem Cell Reports, 18, 12, page (2386-2399)
Statut de publication:Publié, 2023-12
Sujet CREF:Biochimie
Génétique du développement
Biologie cellulaire
Microbiologie et protistologie [bacteriol.,virolog.,mycolog.]
Microbiologie et protistologie [entomologie,phytoparasitolog.]
Microbiologie et protistologie [parasitologie hum. et anim.]
Mots-clés:blood-brain barrier
Cerebral small vessel disease
COL4A1/A2
disease modelling
endothelial cells
extracellular matrix
human induced pluripotent stem cells
matrix metalloproteinases
mural cells
Note générale:SCOPUS: ar.j
Langue:Anglais
Identificateurs:urn:issn:2213-6711
info:doi/10.1016/j.stemcr.2023.10.014
info:pii/S2213671123004162
info:scp/85179444850
info:pmid/37977146