Article révisé par les pairs
Résumé : ostemmachevalieri are used against malaria in traditional medicine in the Democratic Republic ofthe Congo (DRC). To evaluate their potential in the treatment of this disease, the in vitro antiplasmodialproperty of these four plants was evaluated. All experiments were conducted onmethanolic extracts performed on selected organ parts of these plants.Methods: The methanolic extracts, obtained by maceration, were firstly screened in vitro againstthe chloroquine sensitive (3D7) and resistant (W2) Plasmodium falciparum strains by the measurementof lactate dehydrogenase activity, and on human keratinocytes (HaCat) cells by theMTT assay to determine their selectivity indices (SI). Secondly, the antioxidant activity of thesame extracts was evaluated using DPPH and FRAP assays. Finally, the presence of specificphytochemical constituents was evaluated using standard methods and tentatively identified byGC-MS.Results: An optimum antiplasmodial activity (IC50 = 3.4 ± 0.7 μg/mL, for 3D7, SI = 58.2; IC50 = 7± 1.0 μg/mL, for W2, SI = 28.3) was obtained with the leave extract of P. chevalieri. The leaves(for F. stigmatoloba and H. repandum), and the aerial part (for H. repandum) extracts showedpromising and moderate antiplasmodial activities against respectively the 3D7 strain (IC50: <15μg/mL), and W2 strain (IC50:15–50 μg/mL). All extracts presented a weak cytotoxic effect (IC50:>100 μg/mL) on HaCat cells. For the antioxidant test, the most interesting activity was obtainedwith the leaf extract of P. chevalieri. The GC–MS analysis of these four plants species extracts

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