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Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq.

par Nazzari, Marta;Romitti, Mirian ;Hauser, Duncan;Carvalho, Daniel J;Giselbrecht, Stefan;Moroni, Lorenzo;Costagliola, Sabine ;Caiment, Florian
Référence Frontiers in endocrinology, 14, page (1200211)
Publication Publié, 2023-01-01

Article révisé par les pairs

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Résumé :

Phthalates are a class of endocrine-disrupting chemicals that have been shown to negatively correlate with thyroid hormone serum levels in humans and to cause a state of hyperactivity in the thyroid. However, their mechanism of action is not well described at the molecular level.