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Robust Calixarene-Coated Gold Nanorods for Photothermal Therapy

par Lepeintre, Victor ;Camerel, Franck;Lagrost, Corinne;Jabin, Ivan ;Bruylants, Gilles
Référence SFNano 2023 (4-6 December 2023: Montpellier, France), Robust Calixarene-Coated Gold Nanorods for Photothermal Therapy
Publication Non publié, 2023-12-04

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Résumé :

Gold nanorods (AuNRs) have emerged as highly promising materials for advancing biomedical in vivo applications. They exhibit two distinct Localized Surface Plasmon Resonance (LSPR) bands, namely transverse and longitudinal. The maximum absorption wavelength of the latter can be precisely tuned by adjusting the aspect ratio of the rods. For high aspect ratios, the absorption wavelength falls within the near-infrared (NIR) region, where minimal absorption of light by endogenous molecules enables excellent penetration into tissues. Photothermal therapy (PTT) is a promising noninvasive cancer treatment strategy exploiting the conversion of light to heat by photothermal agents for thermal ablation of cancer cells. PTT has attracted much attention due to its simple operation, short treatment duration, and minimal intrusion. AuNRs possess several qualities that make them excellent photothermal agents: high biocompatibility, long circulation times, ease in functionalization, and intense optial extinction coefficients in the NIR region. However, one limitation is their anisotropic structure that is susceptible to deformation upon laser irradiation leading to a rapid decrease of their NIR extinction and photothermal efficiency. To address this challenge, we have employed an effective approach to stabilize the rod shape, involving the use of calix[4]arene-tetradiazonium salts, which can be irreversibly and strongly grafted onto surfaces through the reduction of their diazonium groups. We have adapted this calixarene-based coating technology to fabricate ultrastable AuNRs which exhibit superior stability compared to conventional AuNRs, notably under laser irradiation.