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Kinetic control of liposome size by direct lipid transfer

par Grosfils, Patrick ;Losada Perez, Patricia
Référence Journal of colloid and interface science, 652, page (1381-1393)
Publication Publié, 2023-12-01

Article révisé par les pairs

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Résumé :

Spontaneous lipid vesiculation and related size distribution are traditionally studied in the framework ofequilibrium thermodynamics and continuum mechanics, overlooking the kinetic aspects of the process. In thescenario of liposomes consisting of different lipid molecules dispersed in the same medium - a non-equilibriumsituation -, the system evolves driven by lipid monomer transfer among the different liposomes. This processencompasses time-dependent changes in liposome size and size distribution, thus predicting size and compositionat a given time would entail the control of the size of liposomes by kinetic means, an asset in the frameworkof diagnostics and synthetic biology. We introduce a direct transfer model, based on the fact that monomersare highly reactive species and apply it to saturated phospholipid molecules differing in hydrophobic chainlength. Considering a well-defined gamma-type liposome size distribution, we demonstrate a clear liposome size composition correlation and are able to predict liposome size and size distribution at any time in the transferprocess. The size-composition correlation opens up new prospects for the control of the self-assembling propertiesof lipids and thereby the control of the liposome size.