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Synthesis, physicochemical characteristics, cytocompatibility, and antibacterial properties of iron-doped biphasic calcium phosphate nanoparticles with incorporation of silver

par Nie, Lei ;Chang, Pengbo;Okoro, Oseweuba ;Ayran, Musa;Gunduz, Oguzhan;Hu, Kehui;Wang, Tianwen;Shavandi, Armin
Référence Biomedical Physics & Engineering Express, 9, 6, page (065016)
Publication Publié, 2023-10

Article révisé par les pairs

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Résumé :

Abstract The application of biphasic calcium phosphate (BCP) in tissue engineering and regenerative medicine has been widely explored due to its extensively documented multi-functionality. The present study attempts to synthesize a new type of BCP nanoparticles, characterised with favourable cytocompatibility and antibacterial properties via modifications in their structure, functionality and assemblage, using dopants. In this regard, this study initially synthesized iron-doped BCP (FB) nanoparticles with silver subsequently incorporated into FB nanoparticles to create a nanostructured composite (FB Ag ). The FB and FB Ag nanoparticles were then characterized using Fourier transform infrared spectroscopy, x-ray diffraction, ultraviolet-visible spectroscopy, and x-ray photoelectron spectroscopy. The results showed that silver was present in the FB Ag nanoparticles, with a positive correlation observed between increasing AgNO 3 concentrations and increasing shape irregularity and reduced particle size distribution. Additionally, cell culture tests revealed that both FB and FB Ag nanoparticles were compatible with bone marrow-derived mesenchymal stem cells (hBMSCs). The antibacterial activity of the FB Ag nanoparticles was also tested using Gram-negative E. coli and Gram-positive S. aureus , and was found to be effective against both bacteria. The inhibition rates of FB Ag nanoparticles against E. coli and S. aureus were 33.78 ± 1.69–59.03 ± 2.95%, and 68.48 ± 4.11–89.09 ± 5.35%, respectively. These findings suggest that the FB Ag nanoparticles have potential use in future biomedical applications.