par Hobbi, Parinaz 
;Okoro, Oseweuba ;Nie, Lei ;Shavandi, Amin
Référence Materials Today Sustainability, 24, page (100541)
Publication Publié, 2023
;Okoro, Oseweuba ;Nie, Lei ;Shavandi, Amin Référence Materials Today Sustainability, 24, page (100541)
Publication Publié, 2023
Article révisé par les pairs
| Résumé : | Bone disorders constitute a major problem for public health worldwide. Bone tissue engineering (BTE), which involves the fabrication of a bioactive bone scaffold has provided an effective solution for this global issue. Polyphenolic compound (PPC) as a bioactive molecule can be incorporated into the bone scaffold to promote the bone recovery process. This is because PPCs are recognized as having the potential to enhance the proliferation, migration, and differentiation of bone cells and hydroxyapatite (HA) mineralization for bone formation. In addition, PPCs possess antioxidant, anti-inflammatory, and antibacterial properties, making them effective biomolecules for bone tissue regeneration. Furthermore, the presence of PPCs in easily available and low-cost food and agricultural wastes, with desirable biological characteristics, has promoted an increasing interest in their isolation and further exploitation in tissue engineering. However, the opportunities for the exploration of the PPCs from food and agricultural wastes for their utilization in BTE have not been comprehensively explored and studied. There is, therefore, a necessity to highlight the potential of waste-derived PPCs as a high-value biomass source for employment in BTE. This review discusses the effective applications of PPCs for the fabrication of different polyphenol-functionalized scaffolds for BTE applications. Furthermore, fruit wastes’ potential for the extraction of PPCs with various biological activities is discussed. It is anticipated that this review will help to improve the design and preparation of the next generation of bioactive bone scaffolds, using the fruit waste-derived PPCs. |
