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Balance Between Projecting Neuronal Populations of the Nucleus Accumbens Controls Social Behavior in Mice.

par Le Merrer, Julie;Detraux, Bérangère ;Gandía, Jorge;De Groote, Aurélie ;Fonteneau, Mathieu;de Kerchove d'Exaerde, Alban ;Becker, Jérôme A J
Référence Biological psychiatry, 95, page (123-135)
Publication Publié, 2023-05-01

Article révisé par les pairs

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Résumé :

Deficient social interactions are a hallmark of major neuropsychiatric disorders, and accumulating evidence points to altered social reward and motivation as key underlying mechanisms of these pathologies. In the present study, we further explored the role of the balance of activity between D1 and D2 receptor-expressing striatal projection neurons (D1R- and D2R-SPNs) in the control of social behavior, challenging the hypothesis that excessive D2R-SPN activity, rather than deficient D1R-SPN activity, compromises social behavior.