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Immunotherapy and Targeted Therapies Efficacy in Thymic Epithelial Tumors: A Systematic Review

par Agrafiotis, Apostolos A.C.;Brandão, Mariana;Berghmans, Thierry ;Durieux, Valérie ;Jungels, Christiane
Référence Biomedicines, 11, page (1-19), 2722
Publication Publié, 2023-10-01

Article révisé par les pairs

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Résumé :

Thymic epithelial tumors (TET) are rare neoplasms of the anterior mediastinum. Surgery is the mainstay treatment for resectable TET, whereas systemic treatments are reserved for unresectable and metastatic tumors. The development of new treatments, such as immune checkpoint inhibitors (ICI) and targeted therapies, with promising results in other types of solid tumors, has led to the investigation of their potential efficacy in TET. The study of tumor microenvironments (TME) is another field of investigation that has gained the interest of researchers. Taking into account the complex structure of the thymus and its function in the development of immunity, researchers have focused on TME elements that could predict ICI efficacy.