Résumé : This thesis investigates multiphoton quantum interference with a particular emphasis onphotonic partial distinguishability stemming from factors such as timelags or polarizationmismatches between the photons. We explore the gray area between the behaviour ofdistinguishable classical particles and ideally indistinguishable bosons in large linearinterferometers, with practical implications for photonic quantum computers – especiallyboson samplers – as well as fundamental consequences on the many-body physics ofbosonic systems.Our research leverages recent findings in the mathematical theory of matrix perma-nents to unravel new aspects of interference phenomena. In particular, we exhibit asurprising counterexample to the rule of thumb that "identical bosons bunch most",which can be observed with 7 photons in a 7-mode linear interferometer.We develop robust techniques to validate boson samplers – that is, to verify theincompatibility with classical samplers – by analyzing the photon distribution amongpartitions of the output modes. This innovative method extends existing validationtests, providing a comprehensive approach to assessing boson sampling experiments.An extra contribution of this thesis is the development of BosonSampling.jl, anopen-source, high-performance software package for multiphoton interferometry simula-tions, featuring versatile tools for boson sampling tasks and a suite of validation tools inorder to rigorously evaluate boson samplers in the presence of partial distinguishabilityand other noise sources.