par Fang, Jiaqi
;Bekkouch, Oumaïma;Zeiser, Guilhem;Zubchuk, Yurii;Bizet, Vincent;Blanchard, Nicolas;Evano, Gwilherm ![](/vufind/images/ULB/publications_list.png)
Référence Organic letters, 25, page (6446-6451)
Publication Publié, 2023-08-21
![](/vufind/images/ULB/publications_list.png)
![](/vufind/images/ULB/publications_list.png)
Référence Organic letters, 25, page (6446-6451)
Publication Publié, 2023-08-21
Article révisé par les pairs
Résumé : | Cyanamides possess both nucleophilic and electrophilic centers and their arylation reactions are known to proceed at N(sp3) and C(sp)-sites, leading to N-aryl- cyanamides or amidines. N(sp)-Selectivity has also been reported only in the presence of amines, thus leading to guanidines. Herein, we report a general copper-catalyzed ligand-controlled Chan-Lam-Evans arylation of cyanamides proceeding regioselectively at the N(sp3) or N(sp) atoms and leading to either to N-aryl- cyanamides or dissymmetric carbodiimides. The nature of the ligand, either a bipyridine or a diamine, controls the product distribution and thus offers a divergent entry to useful building blocks from readily available cyanamides. |