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Future prospects of translational and clinical eosinophil research

par Lambrecht, Bart;Aegerter, Helena;Schetters, Sjoerd;Roufosse, Florence ;Hammad, Hamida
Référence ERS Monograph, 2022, page (253-262)
Publication Publié, 2022-02-01

Article révisé par les pairs

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Résumé :

Eosinophils have long been known to contribute to various airway, interstitial and vascular lung diseases. These cells are built to destroy large extracellular helminths, and are loaded with toxic mediators and enzymes to do so. Not surprisingly, eosinophils are also often seen as culprits of cellular damage and loss of homeostasis when they appear in a lung disease. Despite these century-old insights, it is still unknown if all eosinophil subsets have the same pathogenic functions, and it has even emerged that some eosinophils dampen inflammatory reactions. Recent developments in spatial and single-cell transcriptomics, together with availability of powerful biologicals that can deplete eosinophils almost completely in humans with eosinophil-associated lung diseases, are providing important new insights into the fascinating biology of these cells.