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Shear induced diffusion of platelets revisited

par Kotsalos, Christos;Raynaud, Franck;Lätt, Jonas;Dutta, Ritabrata;Dubois, Frank ;Zouaoui Boudjeltia, Karim ;Chopard, Bastien
Référence Frontiers in physiology, 13, page (2148)
Publication Publié, 2022-10-13

Article révisé par les pairs

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Résumé :

The transport of platelets in blood is commonly assumed to obey an advection-diffusion equation with a diffusion constant given by the so-called Zydney-Colton theory. Here we reconsider this hypothesis based on experimental observations and numerical simulations including a fully resolved suspension of red blood cells and platelets subject to a shear. We observe that the transport of platelets perpendicular to the flow can be characterized by a non-trivial distribution of velocities with and exponential decreasing bulk, followed by a power law tail. We conclude that such distribution of velocities leads to diffusion of platelets about two orders of magnitude higher than predicted by Zydney-Colton theory. We tested this distribution with a minimal stochastic model of platelets deposition to cover space and time scales similar to our experimental results, and confirm that the exponential-powerlaw distribution of velocities results in a coefficient of diffusion significantly larger than predicted by the Zydney-Colton theory.