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HIV-Associated Alterations of the Biophysical Features of Maternal Antibodies Correlate With Their Reduced Transfer Across the Placenta.

par Taylor, Sean A;Sharma, Shilpee ;Remmel, Christopher CAL;Holder, Beth;Jones, Christine E;Marchant, Arnaud ;Ackerman, Margaret M.E.
Référence The Journal of infectious diseases, 226, 8, page (1441-1450)
Publication Publié, 2022-10-01

Article révisé par les pairs

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Résumé :

Human immunodeficiency virus (HIV) infection during pregnancy is associated with reduced transplacental transfer of maternal antibodies and increased risk of severe infections in children who are exposed and uninfected with HIV. The basis of this reduced transfer of maternal immunity has not yet been defined but could involve modifications in the biophysical features of antibodies. The objective of this study was to assess the impact of maternal HIV infection on the biophysical features of serum IgG and transplacental antibody transfer.