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Detection of soluble suppression of tumorigenicity 2 and N-terminal B-type natriuretic peptide in a rat model of aortic regurgitation: differential responses to omecamtiv mecarbil.

par El Oumeiri, Bachar Ghassan ;Van De Borne, Philippe ;Hubesch, Geraldine ;Jespers, Pascale ;Dewachter, Laurence ;Stefanidis, Constantin ;McEntee, Kathleen ;Vanden Eynden, Frédéric
Référence Journal of basic & clinical physiology & pharmacology, 33, 6, page (743-750)
Publication Publié, 2022-11

Article révisé par les pairs

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Résumé :

Both N-terminal fragment of B-type natriuretic peptide (NT-proBNP) and soluble isoform of ST2 (sST2) have been identified as biomarkers of heart failure. We evaluated the plasma levels of NT-proBNP and sST2 in a rat model of severe aortic valve regurgitation (AR) and correlated these findings with echocardiographic measurements. We also examined the impact of omecamtiv mecarbil (OM) on these parameters.