par Yin, Nicolas ;Van Nuffelen, Marc ;Bartiaux, Magali ;Preseau, Thierry ;Roggen, Inge ;Delaunoy, Sabrina;Mahadeb, Bhavna ;Dahma, Hafid ;Busson, Laurent ;Vandenberg, Olivier ;Hallin, Marie
Référence RÉUNION INTERDISCIPLINAIRE DE CHIMIOTHÉRAPIE ANTI-INFECTIEUSE (RICAI)(41: 13-14 décembre 2021: Paris)
Publication Publié, 2021-12-14
Abstract de conférence
Résumé : Using rapid respiratory viruses diagnostic tests in the emergency room could allow a better and faster clinical management. Point-of-care PCR instruments provide now results in less than 30 minutes. The objective of this study was to assess the impact of the use of this type of instrument (here the Roche Cobas® Liat Influenza A/B & RSV assay) on the clinical management of emergency room patients.Patients (adults and children) requiring admission or suffering from an underlying condition at risk of respiratory complication were recruited prospectively in the emergency rooms of four hospitals of the Brussels region. Physician’s intentions regarding admission, isolation, antibiotic and antiviral use were collected before and after the completion of an influenza A, B and RSV molecular test. Additionally, the analytical performance of this test was compared to antigen rapid tests and viral culture and its time-to-result was evaluated.PCR yielded twice more positive results than antigen rapid diagnostic tests. It allowed a decrease in the overall need for isolation and treatment by limiting the isolation of negative patient and the antibiotic use for positive patient. Meanwhile, antiviral treatments better targeted patients with a positive influenza PCR.The use of rapid influenza and RSV molecular tests improves the clinical management of patients admitted to the emergency room by providing a fast and reliable result. Their additional cost compared to antigen tests should be balanced with the benefit of their analytical performance, leading to efficient reductions in the need of isolation and antibiotic use.

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