par Hamidi, Masoud 
;Okoro, Oseweuba ;Rashidi, Khodabakhsh;Salami, Mohammad Saeid;Mirzaei Seveiri, Rasool;Hadi, Samadian;Shavandi, Amin
Référence World journal of microbiology & biotechnology
Publication Publié, 2023-01-01
;Okoro, Oseweuba ;Rashidi, Khodabakhsh;Salami, Mohammad Saeid;Mirzaei Seveiri, Rasool;Hadi, Samadian;Shavandi, Amin Référence World journal of microbiology & biotechnology
Publication Publié, 2023-01-01
Article révisé par les pairs
| Résumé : | Microbial exopolysaccharides (EPSs) are mostly produced by bacteria and fungi and have potential use in the production of biomedical products such as nutraceuticals and in tissue engineering applications. The present study investigated the in vitro biological activities and in vivo wound healing effects of EPSs produced from a Sclerotium-forming fungus (Sclerotium glucanicum DSM 2159) and a yeast (Rhodosporidium babjevae), denoted as scleroglucan (Scl) and EPS-R, respectively. EPS yields of 0.9 ± 0.07 g/L and 1.11 ± 0.4 g/L were obtained from S. glucanicum and R. babjevae, respectively. The physicochemical properties of the EPSs were characterized using infrared spectroscopy and scanning electron microscopy. Further investigations of the biological properties showed that both EPSs were cytocompatible toward the human fibroblast cell line and demonstrated hemocompatibility. Favorable wound healing capacities of the EPSs (10 mg/mL) were also established via in vivo tests. The present study therefore showed that the EPSs produced by S. glucanicum and R. babjevae have the potential use as biocompatible components for the promotion of dermal wound healing. |
