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Severe autoimmune thyroiditis in transgenic NOD.H2h4 mice expressing interleukin-4 in the thyroid.

par Merakchi, Karima ;Djerbib, Sami ;Dumont, Jacques E;Miot, Françoise ;De Deken, Xavier
Référence Thyroid, 33, 3, page (351-364)
Publication Publié, 2023-06-01

Article révisé par les pairs

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Résumé :

Hashimoto's thyroiditis is a common autoimmune thyroid disorder characterized by thyroid lymphocytic infiltrates and autoreactive antibodies against thyroglobulin (TgAbs) and thyroperoxidase. Final evolution of the disease can lead to hypothyroidism with destruction of the thyroid architecture. Interleukine-4 (IL-4) is involved in the humoral immune response and B cell activation required in autoimmune thyroiditis (AT) progression. We used our mouse model overexpressing IL-4 by thyrocytes (Thyr-IL4) to study the impact of a local IL-4 expression in AT using transgenic NOD.H2h4 derived animals treated with iodide-supplemented water to increase the incidence of spontaneous AT (SAT).