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Transmembrane Transport of Ions by Calixarene-based Receptors

par Valkenier, Hennie
Référence Calix2022 (16th International Conference on Calixarenes: 10-14 July 2022: New Orleans, Louisiana, USA)
Publication Non publié, 2022-07-11

Communication à un colloque

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Résumé :

Absence or malfunction of membrane proteins acting as ion channels is the cause of several channelopathies, such as cystic fibrosis. Synthetic ion carriers could take over the function of these proteins. Such carriers extract the ion from the aqueous phase into the membrane, move it across the apolar interior of the lipid bilayer while shielding its charge, to then release it on the other side of the membrane.Calixarenes have various characteristics which make them attractive scaffolds for the development of ion carriers: 1) Their lipophilicity allows them to readily partition into lipid bilayer membranes; 2) They can be easily functionalised with a wide range of groups for ion binding; 3) They have an attractive combination of preorganisation and conformational flexibility, allowing to accommodate binding groups of different sizes; 4) The cavity of calix[6]arenes can contribute to the transport of cations. Here, we present a series of calix[6]arene-based anion transporters and their remarkable transport properties, including >100-fold selectivity for Cl− uniport over HCl symport when functionalised with halogen bonding donor groups.