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Retrospective analysis of the immunogenic effects of intra-arterial locoregional therapies in hepatocellular carcinoma: a rationale for combining selective internal radiation therapy (SIRT) and immunotherapy.

par Craciun, Ligia;de Wind, Roland;Demetter, Pieter ;Lucidi, Valerio ;Bohlok, Ali ;Michiels, Sébastien ;Bouazza, Fikri ;Vouche, Michael ;Tancredi, I.;Verset, Gontran ;Garaud, Soizic ;Naveaux, Céline;Galdon, Maria Gomez;Willard-Gallo, Karen ;Hendlisz, Alain ;Duran Derijckere, Ivan ;Flamen, Patrick ;Larsimont, Denis ;Donckier De Donceel, Vincent
Référence BMC cancer, 20, 1, page (135)
Publication Publié, 2020-02-01

Article révisé par les pairs

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Résumé :

Immunotherapy represents a promising option for treatment of hepatocellular carcinoma (HCC) in cirrhotic patients but its efficacy is currently inconsistent and unpredictable. Locoregional therapies inducing immunogenic cell death, such as transarterial chemoembolization (TACE) or selective internal radiation therapy (SIRT), have the potential to act synergistically with immunotherapy. For the development of new approaches combining locoregional treatments with immunotherapy, a better understanding of the respective effects of TACE and SIRT on recruitment and activation of immune cells in HCC is needed. To address this question, we compared intra-tumor immune infiltrates in resected HCC after preoperative treatment with TACE or SIRT.